Category: antidepressants

My Experiences with Tranylcypromine: The Most Powerful Antidepressant Ever?

by wallowinmaya | Posted on April 6, 2017 | 17 Comments

First written: April 2017. Last updated: December 2017. Introduction Tranylcypromine (brand name: “Parnate“) is a nonselective and irreversible monoamine oxidase inhibitor (MAOI) used to treat major depressive disorder. See this previous post of mine about MAOIs (written in 2013). Prophetically enough, I wrote: “So my current plan is to first try Moclobemide and then Selegiline. If

The Good Drug Guide and the Holy Grail of Chemical Paradise: MAOIs

by wallowinmaya | Posted on February 20, 2013 | 4 Comments

[Epistemic status: MAOIs probably are the most powerful antidepressants – more evidence for this can be found in an excellent recent post on SlateStarCodex.] I’ve recently read the absolutely excellent classic “The Good Drug Guide” by David Pearce. Pearce is a hardcore transhumanist whose ultimate goal is to abolish all suffering. Even better, he’s not shying away